Biology:GPR174
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene.[1]
Ligands
- Agonists
- GPR174 has been reported to bind to lysophosphatidylserine (LysoPS), and this appears to be the endogenous agonist.[2][3]
- Antagonists
- N-acyl derivatives of LysoPS act as antagonists at GPR174.[4]
References
- ↑ "Entrez Gene: GPR174 G protein-coupled receptor 174". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=84636.
- ↑ "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.". PLOS Biology 21 (12). Dec 2023. doi:10.1371/journal.pbio.3002387. PMID 38048360.
- ↑ "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling.". Nature Communications 14 (1). Sep 2023. doi:10.1038/s41467-023-41654-3. PMID 37737235.
- ↑ "Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine". Journal of Medicinal Chemistry 64 (14): 10059–10101. July 2021. doi:10.1021/acs.jmedchem.1c00347. PMID 34233115.
Further reading
- "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Letters 520 (1–3): 97–101. Jun 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. Bibcode: 2002FEBSL.520...97T.
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