Biology:GPR6
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[1][2]
Function
GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[3]
GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[4]
Ligand
Inverse Agonist
Evolution
Paralogues to GPR6 gene
Source:[6]
- GPR3
- GPR12
- S1PR5
- S1PR1
- CNR1
- S1PR2
- LPAR2
- CNR2
- MC1R
- S1PR3
- S1PR4
- GPR119
- MC3R
- MC4R
- MC5R
- LPAR1
- LPAR3
- MC2R
See also
References
- ↑ "Entrez Gene: GPR6 G protein-coupled receptor 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2830.
- ↑ "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics 28 (2): 347–349. July 1995. doi:10.1006/geno.1995.1154. PMID 8530049. https://zenodo.org/record/1229665.
- ↑ "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling 14 (11): 941–953. November 2002. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
- ↑ "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry 282 (14): 10506–10515. April 2007. doi:10.1074/jbc.M700911200. PMID 17284443.
- ↑ "GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol". Acta Pharmacologica Sinica 40 (3): 300–308. March 2019. doi:10.1038/s41401-018-0031-9. PMID 29941868.
- ↑ "GeneCards®: The Human Gene Database". https://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR6&keywords=gpr6#paralogs.
Further reading
- "Isolation of three novel human genes encoding G protein-coupled receptors". DNA and Cell Biology 14 (1): 25–35. January 1995. doi:10.1089/dna.1995.14.25. PMID 7832990.
- "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics 28 (2): 347–349. July 1995. doi:10.1006/geno.1995.1154. PMID 8530049. https://zenodo.org/record/1229665.
- "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry 13 (2): 75–84. 2003. doi:10.1159/000070251. PMID 12649592.
External links
- "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3091.
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