Biology:Prolactin-releasing peptide receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

PrRPR is a G-protein coupled receptor that binds the prolactin-releasing peptide (PRLH).

Function

PrRPR is a 7-transmembrane domain receptor for prolactin-releasing peptide that is highly expressed in the anterior pituitary.

Further reading

• "The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.". J. Mol. Med. 77 (6): 495–504. 1999. doi:10.1007/s001090050403. PMID 10475064. 
• "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.". Genomics 29 (2): 335–44. 1996. doi:10.1006/geno.1995.9996. PMID 8666380. 
• "A prolactin-releasing peptide in the brain.". Nature 393 (6682): 272–6. 1998. doi:10.1038/30515. PMID 9607765. Bibcode: 1998Natur.393..272H. 
• "Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.". Regul. Pept. 83 (1): 1–10. 1999. doi:10.1016/S0167-0115(99)00028-2. PMID 10498338. 
• "Characterization of the binding of [(125)I-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor."]. Br. J. Pharmacol. 131 (4): 683–8. 2000. doi:10.1038/sj.bjp.0703617. PMID 11030716. 
• "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.". Mol. Pharmacol. 60 (5): 916–23. 2001. doi:10.1124/mol.60.5.916. PMID 11641419. 
• "Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region.". Mol. Endocrinol. 16 (4): 785–98. 2002. doi:10.1210/me.16.4.785. PMID 11923475. 
• "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.". Peptides 23 (6): 1135–40. 2003. doi:10.1016/S0196-9781(02)00046-3. PMID 12126742. 
• "NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.". FEBS Lett. 531 (2): 193–8. 2002. doi:10.1016/S0014-5793(02)03502-0. PMID 12417311. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.". Diabetes 52 (5): 1296–9. 2003. doi:10.2337/diabetes.52.5.1296. PMID 12716769. 
• "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. 2004. doi:10.1038/nature02462. PMID 15164054. Bibcode: 2004Natur.429..375D. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.". Peptides 26 (4): 675–81. 2005. doi:10.1016/j.peptides.2004.11.020. PMID 15752583. 
• "Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.". Genomics 85 (6): 688–703. 2005. doi:10.1016/j.ygeno.2005.02.007. PMID 15885496. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 

External links

• "Prolactin-Releasing Peptide Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3018. 
• PRLHR+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.