Biology:TAS2R5

Generic protein structure example

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene.

Function

This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception.

See also

• Taste receptor

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719. 
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554. 
• "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. 2002. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. 
• "The receptors and cells for mammalian taste.". Nature 444 (7117): 288–94. 2007. doi:10.1038/nature05401. PMID 17108952. 
• "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. 
• "A novel family of mammalian taste receptors.". Cell 100 (6): 693–702. 2000. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. 
• "T2Rs function as bitter taste receptors.". Cell 100 (6): 703–11. 2000. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935. 
• Firestein S (2000). "The good taste of genomics.". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221. 
• "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601–4. 2000. doi:10.1038/35007072. PMID 10766242. 
• "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. 2003. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. 
• "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. 2005. doi:10.1093/molbev/msi027. PMID 15496549. 
• "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313–26. 2006. doi:10.1534/genetics.104.037523. PMID 15744053. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.