Biology:LPAR1
 Generic protein structure example |
Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene.[1][2][3] LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]
Function
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.[1]
Cancer
LPAR1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[5] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[5]
Evolution
Paralogues[6]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1902.
- ↑ "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. November 1996. doi:10.1083/jcb.135.4.1071. PMID 8922387.
- ↑ "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. February 1997. doi:10.1006/bbrc.1997.6150. PMID 9070858.
- ↑ "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. January 2010. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
- ↑ 5.0 5.1 "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes.". J Cell Physiol 230 (4): 802–812. April 2015. doi:10.1002/jcp.24808. PMID 25205602.
- ↑ "GeneCards®: The Human Gene Database". https://www.genecards.org/cgi-bin/carddisp.pl?gene=LPAR1&keywords=LPAR1#paralogs.
Further reading
- "Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate.". J. Cell. Biochem. Suppl. 30–31: 147–57. 1999. PMID 9893266.
- "Lysophosphatidic acid receptors.". Mol. Pharmacol. 58 (6): 1188–96. 2001. doi:10.1124/mol.58.6.1188. PMID 11093753.
- "Lysophosphatidic acid: G-protein signalling and cellular responses.". Curr. Opin. Cell Biol. 9 (2): 168–73. 1997. doi:10.1016/S0955-0674(97)80059-2. PMID 9069262.
- "A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151–6. 1998. doi:10.1073/pnas.95.11.6151. PMID 9600933. Bibcode: 1998PNAS...95.6151F.
- "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.". Mol. Pharmacol. 54 (5): 881–8. 1998. doi:10.1124/mol.54.5.881. PMID 9804623.
- "Immunohistological localization of the myelinating cell-specific receptor LP(A1).". Glia 38 (2): 126–36. 2002. doi:10.1002/glia.10054. PMID 11948806.
- "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.". FEBS Lett. 523 (1–3): 187–92. 2002. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830.
- "Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.". J. Biol. Chem. 278 (1): 400–6. 2003. doi:10.1074/jbc.M210151200. PMID 12393875.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway.". J. Cell Sci. 116 (Pt 10): 1969–80. 2004. doi:10.1242/jcs.00397. PMID 12668728.
- "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.". Cancer Res. 63 (7): 1706–11. 2003. PMID 12670925.
- "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. 2003. doi:10.1038/sj.onc.1206406. PMID 12761501.
- "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.". J. Biol. Chem. 279 (11): 10459–68. 2004. doi:10.1074/jbc.M311891200. PMID 14688263.
- "The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas.". Hepatogastroenterology 50 (54): 1770–3. 2004. PMID 14696401.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.". FASEB J. 18 (11): 1309–11. 2005. doi:10.1096/fj.03-1050fje. PMID 15208267.
External links
- "Lysophospholipid Receptors: LPA1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2990.
- Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
