Biology:Melanin-concentrating hormone receptor
From HandWiki
Short description: InterPro Family
| melanin-concentrating hormone receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | MCHR1 |
| Alt. symbols | GPR24 |
| NCBI gene | 2847 |
| HGNC | 4479 |
| OMIM | 601751 |
| RefSeq | NM_005297 |
| UniProt | Q99705 |
| Other data | |
| Locus | Chr. 22 q13.3 |
| melanin-concentrating hormone receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | MCHR2 |
| Alt. symbols | GPR145 |
| NCBI gene | 84539 |
| HGNC | 20867 |
| OMIM | 606111 |
| RefSeq | NM_032503 |
| UniProt | Q969V1 |
| Other data | |
| Locus | Chr. 6 q16 |
Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.
- MCH-R1 is expressed in all mammals.
- MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.
Clinical significance
Antagonists might be useful in the treatment of obesity[1][2] and anxiety and depression.[3] An agonist might have possible utility as a treatment for osteoporosis[4] and insomnia[5]
Research is ongoing for antagonists affecting MCH receptors R1 and R2.[6][7]
See also
- Melanin concentrating hormone
- Melanin
References
- ↑ "Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity". J. Med. Chem. 49 (14): 4017–22. 2006. doi:10.1021/jm058239j. PMID 16821761.
- ↑ Luthin DR (2007). "Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists". Life Sci. 81 (6): 423–40. doi:10.1016/j.lfs.2007.05.029. PMID 17655875.
- ↑ "Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders". CNS Drugs 20 (10): 801–11. 2006. doi:10.2165/00023210-200620100-00002. PMID 16999451.
- ↑ "Osteoporosis in MCHR1-deficient mice". Biochem. Biophys. Res. Commun. 318 (4): 964–9. 2004. doi:10.1016/j.bbrc.2004.04.122. PMID 15147966.
- ↑ "Melanin-concentrating hormone control of sleep-wake behavior.". Sleep Med Rev 17 (4): 293–8. August 2013. doi:10.1016/j.smrv.2012.10.002. PMID 23477948.
- ↑ "Identification of melanin-concentrating hormone receptor and its impact on drug discovery". Journal of Experimental Zoology Part A: Comparative Experimental Biology 305 (9): 761–8. 2006. doi:10.1002/jez.a.311. PMID 16902961.
- ↑ McBriar MD (2006). "Recent advances in the discovery of melanin-concentrating hormone receptor antagonists". Current Opinion in Drug Discovery & Development 9 (4): 496–508. PMID 16889232.
External links
- "Melanin-Concentrating Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1339.
- melanin-concentrating+hormone+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
- MCHR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- MCHR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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