Biology:Melanin-concentrating hormone receptor 2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.[1][2][3]
MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.
Clinical significance
Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.[4]
See also
References
- ↑ "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84539.
- ↑ "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. May 2001. doi:10.1006/bbrc.2001.4893. PMID 11355873.
- ↑ "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. June 2001. doi:10.1074/jbc.M102068200. PMID 11274220.
- ↑ "Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction". Horm. Metab. Res. 42 (7): 521–7. June 2010. doi:10.1055/s-0030-1249019. PMID 20340065.
External links
- "Melanin-Concentrating Hormone Receptors: MCH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2999.
Further reading
- "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. 2001. doi:10.1073/pnas.121170598. PMID 11404457. Bibcode: 2001PNAS...98.7564S.
- "Identification and characterization of a melanin-concentrating hormone receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. 2001. doi:10.1073/pnas.131200698. PMID 11416225. Bibcode: 2001PNAS...98.7576A.
- "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.". J. Biol. Chem. 276 (37): 34664–70. 2001. doi:10.1074/jbc.M102601200. PMID 11459838.
- "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.". Biochemistry 40 (31): 9379–86. 2001. doi:10.1021/bi010867p. PMID 11478907.
- "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.". J. Biol. Chem. 277 (16): 13821–6. 2002. doi:10.1074/jbc.M200563200. PMID 11839762.
- "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.". Biochem. Biophys. Res. Commun. 295 (4): 841–8. 2002. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971.
- "The structure and evolution of the melanocortin and MCH receptors in fish and mammals.". Genomics 81 (2): 184–91. 2003. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396.
- "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.". Proteins 56 (3): 430–48. 2004. doi:10.1002/prot.20125. PMID 15229878.
- "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.". Obes. Res. 12 (8): 1327–34. 2004. doi:10.1038/oby.2004.167. PMID 15340116.
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