Biology:TAS2R16
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TAS2R16 (taste receptor, type 2, member 16) is a human gene that encodes for a receptor that may play a role in the perception of bitterness.[1][2]
The TAS2R16 gene is located on the long (q) arm of chromosome 7 at position 31.1 - 31.3, from base pair 122,228,764 to base pair 122,229,639.
Clinical significance
Variants of this gene have been linked to an increased risk for alcohol dependence.[3]
There is an East African origin for high salicin sensitivity, and thus sensitivity to bitterness in people from this region, with this phenotype matched to TAS2R16 variants.[4]
See also
References
- ↑ "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet 32 (3): 397–401. 2002. doi:10.1038/ng1014. PMID 12379855.
- ↑ Drewnowski A (2001). "The science and complexity of bitter taste". Nutr Rev 59 (6): 163–9. doi:10.1111/j.1753-4887.2001.tb07007.x. PMID 11444592.
- ↑ "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence". Am. J. Hum. Genet. 78 (1): 103–11. 2006. doi:10.1086/499253. PMID 16385453.
- ↑ "Origin and Differential Selection of Allelic Variation at TAS2R16 Associated with Salicin Bitter Taste Sensitivity in Africa". Mol Biol Evol 31 (2): 288–302. 2014. doi:10.1093/molbev/mst211. PMID 24177185. PMC 3907056. http://mbe.oxfordjournals.org/content/31/2/288.
Further reading
- Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
- "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. 2002. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- "A novel family of mammalian taste receptors.". Cell 100 (6): 693–702. 2000. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
- "T2Rs function as bitter taste receptors.". Cell 100 (6): 703–11. 2000. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
- Firestein S (2000). "The good taste of genomics.". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.
- "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601–4. 2000. doi:10.1038/35007072. PMID 10766242.
- "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.". Nat. Genet. 32 (3): 397–401. 2002. doi:10.1038/ng1014. PMID 12379855.
- "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. 2003. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. 2005. doi:10.1093/molbev/msi027. PMID 15496549.
- "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313–26. 2006. doi:10.1534/genetics.104.037523. PMID 15744053.
- "The receptors and coding logic for bitter taste.". Nature 434 (7030): 225–9. 2005. doi:10.1038/nature03352. PMID 15759003.
- "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.". Am. J. Hum. Genet. 78 (1): 103–11. 2006. doi:10.1086/499253. PMID 16385453.
- "Members of RTP and REEP gene families influence functional bitter taste receptor expression.". J. Biol. Chem. 281 (29): 20650–9. 2006. doi:10.1074/jbc.M513637200. PMID 16720576.
External links
- GeneCard for TAS2R16
- TAS2R16+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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