Biology:S1PR2
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Short description: Protein and coding gene in humans
 Generic protein structure example |
Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P2, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[1]
Function
This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[1] It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor.[2] S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.[3] [4]
Evolution
Paralogues[5]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9294.
- ↑ "The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity". PLOS Biology 12 (1): e1001763. 14 January 2014. doi:10.1371/journal.pbio.1001763. PMID 24453941.
- ↑ "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke". Proceedings of the National Academy of Sciences 116 (28): 14270–14279. 9 July 2019. doi:10.1073/pnas.1905309116. PMID 31235580.
- ↑ "Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair". Trends in Neurosciences 42 (9): 644–656. September 2019. doi:10.1016/j.tins.2019.05.006. PMID 31285047.
- ↑ "GeneCards®: The Human Gene Database". https://www.genecards.org/cgi-bin/carddisp.pl?gene=S1PR2&keywords=s1pr2#paralogs.
Further reading
- "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905 (1): 54–60. 2000. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. Bibcode: 2000NYASA.905...54S.
- "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. 2002. PMID 11915348.
- "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development.". Mol. Cell. Neurosci. 5 (3): 201–9. 1994. doi:10.1006/mcne.1994.1024. PMID 8087418.
- "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.". Biochem. Biophys. Res. Commun. 227 (2): 608–14. 1996. doi:10.1006/bbrc.1996.1553. PMID 8878560.
- "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.". J. Biol. Chem. 274 (8): 4626–32. 1999. doi:10.1074/jbc.274.8.4626. PMID 9988698.
- "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. 1999. doi:10.1074/jbc.274.27.18997. PMID 10383399.
- "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. 1999. doi:10.1074/jbc.274.39.27351. PMID 10488065.
- "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.". J. Biol. Chem. 275 (1): 288–96. 2000. doi:10.1074/jbc.275.1.288. PMID 10617617.
- "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.". Mol. Pharmacol. 58 (2): 449–54. 2000. doi:10.1124/mol.58.2.449. PMID 10908314.
- "Sphingosine 1-phosphate receptors.". Prostaglandins 64 (1–4): 135–142. April 2001. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
- "Cell type-specific localization of human cardiac S1P receptors.". J. Histochem. Cytochem. 50 (5): 661–70. 2002. doi:10.1177/002215540205000507. PMID 11967277.
- "Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.". Biochem. Biophys. Res. Commun. 299 (3): 483–7. 2003. doi:10.1016/S0006-291X(02)02671-2. PMID 12445827.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.". J. Invest. Dermatol. 120 (4): 693–700. 2003. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
- "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.". FASEB J. 18 (11): 1309–11. 2005. doi:10.1096/fj.03-1050fje. PMID 15208267.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.". Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4312–7. 2005. doi:10.1073/pnas.0409784102. PMID 15764699. Bibcode: 2005PNAS..102.4312S.
- "Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN.". Arterioscler. Thromb. Vasc. Biol. 27 (6): 1312–8. 2007. doi:10.1161/ATVBAHA.107.143735. PMID 17431187.
External links
- "Lysophospholipid Receptors: S1P2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2994.
- Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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