Biology:GPR88

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Probable G-protein coupled receptor 88 is a protein that in humans is encoded by the GPR88 gene.[1][2][3][4][5]

Ligands

Agonists

References

  1. "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  2. Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  3. Mizushima K; Miyamoto Y; Tsukahara F et al. (2001). "A novel G-protein-coupled receptor gene expressed in striatum". Genomics 69 (3): 314–21. doi:10.1006/geno.2000.6340. PMID 11056049. 
  4. Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode2002PNAS...9916899M. 
  5. "GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation". Basal Ganglia 1 (2): 83–89. 2011. doi:10.1016/j.baga.2011.04.001. PMID 21804954. 
  6. Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R, Darcq E, Kieffer BL, Jin C (Feb 2023). "Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation". J Med Chem 66 (4): 2964–2978. doi:10.1021/acs.jmedchem.2c01983. PMID 36749855.