Biology:Somatostatin receptor 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene.

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.

See also

• Somatostatin receptor

Further reading

• "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America 89 (1): 251–5. January 1992. doi:10.1073/pnas.89.1.251. PMID 1346068. Bibcode: 1992PNAS...89..251Y. 
• "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sciences 55 (23): 1797–806. 1994. doi:10.1016/0024-3205(94)90090-6. PMID 7968260. 
• "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters 331 (1–2): 53–9. September 1993. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. 
• "Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae". Life Sciences 58 (13): 1091–8. 1996. doi:10.1016/0024-3205(96)00063-X. PMID 8622562. 
• "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications 232 (1): 157–63. March 1997. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
• "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics 42 (3): 499–506. June 1997. doi:10.1006/geno.1997.4763. PMID 9205124. 
• "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". European Journal of Clinical Investigation 27 (8): 639–44. August 1997. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
• "In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells". Endocrinology 140 (1): 373–80. January 1999. doi:10.1210/endo.140.1.6398. PMID 9886848. 
• "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes 48 (1): 77–85. January 1999. doi:10.2337/diabetes.48.1.77. PMID 9892225. 
• "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". The Journal of Biological Chemistry 275 (11): 7862–9. March 2000. doi:10.1074/jbc.275.11.7862. PMID 10713101. 
• "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast". The Journal of Biological Chemistry 275 (13): 9557–62. March 2000. doi:10.1074/jbc.275.13.9557. PMID 10734105. 
• "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism 86 (5): 2161–9. May 2001. doi:10.1210/jcem.86.5.7489. PMID 11344221. 
• "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study". Investigative Ophthalmology & Visual Science 42 (10): 2193–201. September 2001. PMID 11527930. 
• "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica 26 (3): 175–9. September 2001. PMID 11753241. 
• "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv 440 (5): 461–75. May 2002. doi:10.1007/s00428-002-0609-x. PMID 12021920. 
• "Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line". Biochemical and Biophysical Research Communications 297 (4): 828–34. October 2002. doi:10.1016/S0006-291X(02)02307-0. PMID 12359227. 
• "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". American Journal of Physiology. Endocrinology and Metabolism 283 (5): E1056-66. November 2002. doi:10.1152/ajpendo.00205.2001. PMID 12376335. 
• "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". The Journal of Clinical Endocrinology and Metabolism 87 (11): 5125–9. November 2002. doi:10.1210/jc.2002-020790. PMID 12414882. 
• "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urologic Oncology 7 (3): 91–8. 2002. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541. 

External links

• "Somatostatin Receptors: sst₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2439. 
• somatostatin+receptor+type+1 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.