Biology:P2RY1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

Function

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

See also

References

  1. "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications 218 (3): 783–8. January 1996. doi:10.1006/bbrc.1996.0139. PMID 8579591. 
  2. "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5028. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.