Biology:P2RY1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.

Function

The product of this gene, P2Y₁ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

See also

• P2Y receptor

Further reading

• "Cloning and tissue distribution of the human P2Y1 receptor". Biochemical and Biophysical Research Communications 221 (3): 588–93. April 1996. doi:10.1006/bbrc.1996.0640. PMID 8630005. https://dipot.ulb.ac.be/dspace/bitstream/2013/50234/4/d2e5b4da-6bd0-4540-86dc-20629565c59a.txt. 
• "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor". Gene 171 (2): 295–7. June 1996. doi:10.1016/0378-1119(96)00027-3. PMID 8666290. 
• "The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells". FEBS Letters 403 (1): 26–30. February 1997. doi:10.1016/S0014-5793(97)00022-7. PMID 9038354. 
• "Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1)". Somatic Cell and Molecular Genetics 22 (5): 419–24. September 1996. doi:10.1007/BF02369897. PMID 9039850. 
• "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochemical and Biophysical Research Communications 237 (2): 297–302. August 1997. doi:10.1006/bbrc.1997.7135. PMID 9268704. 
• "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets". The Journal of Biological Chemistry 273 (4): 2030–4. January 1998. doi:10.1074/jbc.273.4.2030. PMID 9442040. 
• "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins". Proceedings of the National Academy of Sciences of the United States of America 95 (15): 8496–501. July 1998. doi:10.1073/pnas.95.15.8496. PMID 9671706. Bibcode: 1998PNAS...95.8496H. 
• "Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells". British Journal of Pharmacology 132 (2): 393–402. January 2001. doi:10.1038/sj.bjp.0703843. PMID 11159687. 
• "Heteromeric association creates a P2Y-like adenosine receptor". Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7617–22. June 2001. doi:10.1073/pnas.121587098. PMID 11390975. 
• "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve". Neuroscience Letters 312 (1): 33–6. October 2001. doi:10.1016/S0304-3940(01)02189-9. PMID 11578839. 
• "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1521 (1–3): 107–19. October 2001. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642. 
• "ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12)". FEBS Letters 513 (2–3): 179–83. February 2002. doi:10.1016/S0014-5793(02)02255-X. PMID 11904146. 
• "Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase". Biochemical Pharmacology 64 (3): 433–9. August 2002. doi:10.1016/S0006-2952(02)01113-9. PMID 12147294. 
• "Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system". Blood 101 (4): 1400–8. February 2003. doi:10.1182/blood-2002-02-0642. PMID 12393588. 
• "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors". The Journal of Investigative Dermatology 120 (3): 440–7. March 2003. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858. 
• "Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets". Platelets 14 (1): 15–20. February 2003. doi:10.1080/0953710021000062914. PMID 12623443. 
• "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". The Journal of Investigative Dermatology 120 (6): 1007–15. June 2003. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128. 
• "Quantification of ADP and ATP receptor expression in human platelets". Journal of Thrombosis and Haemostasis 1 (2): 330–6. February 2003. doi:10.1046/j.1538-7836.2003.00070.x. PMID 12871508. 

External links

• "P2Y Receptors: P2Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2392. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.