Biology:Bombesin-like receptor 3
 Generic protein structure example |
The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]
Function
Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]
BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]
References
- ↑ "Bombesin Receptors: BB3". International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958.
- ↑ 2.0 2.1 2.2 "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. March 1993. doi:10.1016/S0021-9258(18)53415-3. PMID 8383682.
- ↑ 3.0 3.1 "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. July 1997. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170.
- ↑ "Entrez Gene: BRS3 bombesin-like receptor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=680.
- ↑ "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. 1997. doi:10.1074/jbc.272.41.26062. PMID 9325344.
- ↑ "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. 2007. doi:10.1124/pr.107.07108. PMID 18055507.
Further reading
- "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus". FEBS Lett. 340 (3): 260–4. 1994. doi:10.1016/0014-5793(94)80150-9. PMID 8131855. https://opus.bibliothek.uni-wuerzburg.de/files/2664/Gorboulev_chromosomal.pdf.
- "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. 1993. doi:10.1016/S0021-9258(18)53415-3. PMID 8383682.
- "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides 17 (1): 111–8. 1996. doi:10.1016/0196-9781(95)02088-8. PMID 8822519.
- "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity". Nature 390 (6656): 165–9. 1997. doi:10.1038/36568. PMID 9367152. Bibcode: 1997Natur.390..165O.
- "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3". J. Biol. Chem. 273 (22): 13613–24. 1998. doi:10.1074/jbc.273.22.13613. PMID 9593699.
- "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)". Biochemistry 41 (28): 8954–60. 2002. doi:10.1021/bi0202777. PMID 12102638.
- "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells". Lung Cancer 54 (2): 143–8. 2007. doi:10.1016/j.lungcan.2006.08.005. PMID 16979789.
- "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells". Biochem. J. 405 (1): 131–7. 2007. doi:10.1042/BJ20061754. PMID 17355223.
External links
- "Bombesin Receptors: BB3". International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958.
- bombesin+receptor+subtype+3 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human BRS3 genome location and BRS3 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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