Biology:Pancreatic polypeptide receptor 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.[1][2][3]
Selective Ligands
Agonists
- Pancreatic polypeptide
- Neuropeptide Y (endogenous agonist, non subtype selective)
- Peptide YY
- GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Antagonists
See also
References
- ↑ "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287–290. December 1997. doi:10.1006/geno.1997.5024. PMID 9417917.
- ↑ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5540.
- ↑ "The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis: Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio" (in en). Medical and Pharmaceutical Journal 1 (2). 2022-12-02. doi:10.55940/medphar20227. ISSN 2957-6067. http://pharmacoj.com/ojs/index.php/Medph/article/view/10.
- ↑ "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research 27 (4): 217–233. 2007. doi:10.1080/10799890701505206. PMID 17885919.
External links
- "Neuropeptide Y Receptors: Y4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2370.
Further reading
- "Structure and receptor binding of PYY analogs". Peptides 23 (2): 305–321. February 2002. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645.
- "Clinical potentials of neuropeptide Y family of hormones". American Journal of Surgery 183 (4): 430–434. April 2002. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.
- "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2–3): 173–187. April 2002. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
- "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry 269 (15): 3619–3631. August 2002. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
- "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY". The Journal of Biological Chemistry 270 (49): 29123–29128. December 1995. doi:10.1074/jbc.270.49.29123. PMID 7493937.
- "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY". The Journal of Biological Chemistry 270 (45): 26762–26765. November 1995. doi:10.1074/jbc.270.45.26762. PMID 7592911.
- "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America 93 (10): 4661–4665. May 1996. doi:10.1073/pnas.93.10.4661. PMID 8643460. Bibcode: 1996PNAS...93.4661Y.
- "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–458. January 1997. doi:10.1038/385454a0. PMID 9009195. Bibcode: 1997Natur.385..454K.
- "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14". Genomics 46 (3): 513–515. December 1997. doi:10.1006/geno.1997.5071. PMID 9441761.
- "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry 38 (14): 4365–4373. April 1999. doi:10.1021/bi982900m. PMID 10194355.
- "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". The Journal of Biological Chemistry 274 (28): 19894–19900. July 1999. doi:10.1074/jbc.274.28.19894. PMID 10391935.
- "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell 101 (4): 365–376. May 2000. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164.
- "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Molecular and Cellular Biology 21 (20): 6841–6850. October 2001. doi:10.1128/MCB.21.20.6841-6850.2001. PMID 11564868.
- "NPY regulates catecholamine secretion from human adrenal chromaffin cells". The Journal of Clinical Endocrinology and Metabolism 86 (12): 5956–5963. December 2001. doi:10.1210/jcem.86.12.8091. PMID 11739470.
- "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology 135 (6): 1505–1512. March 2002. doi:10.1038/sj.bjp.0704604. PMID 11906964.
- "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". The Journal of Biological Chemistry 277 (31): 27706–27715. August 2002. doi:10.1074/jbc.M200955200. PMID 12016208.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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