Biology:TAAR6
 Generic protein structure example |
Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[1][2]
Function
TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[3][4] RNA expression analysis shows hTAAR6 is expressed in the hippocampus, where murine TAAR receptors have been shown to be involved with neurogenesis.[5]
Computational modeling suggests TAAR6 can bind to the foul smelling compounds produced by rotting flesh, putrescine and cadaverine.[6]
TAAR6 mutant mice have differences in behavior compared with wild-type mice.[7] Also, they have elevated brain serotonin levels in several brain regions and enhanced hypothermic response to 5-HT1A receptor agonist 8-OH-DPAT.[8]
References
- ↑ "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America 98 (16): 8966–71. July 2001. doi:10.1073/pnas.151105198. PMID 11459929.
- ↑ "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. March 2005. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- ↑ "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". American Journal of Human Genetics 75 (4): 624–38. October 2004. doi:10.1086/424887. PMID 15329799.
- ↑ "Entrez Gene: TAAR6 trace amine associated receptor 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=319100.
- ↑ "Expression of Trace Amine-Associated Receptors in the Murine and Human Hippocampus Based on Public Transcriptomic Data". Cells 11 (11): 1813. June 2022. doi:10.3390/cells11111813. PMID 35681508.
- ↑ "Identifying human diamine sensors for death related putrescine and cadaverine molecules". PLOS Computational Biology 14 (1): e1005945. January 2018. doi:10.1371/journal.pcbi.1005945. PMID 29324768. Bibcode: 2018PLSCB..14E5945I.
- ↑ "Identifying the function of trace amine-associated receptor 6 and its role in behavior, physiology and brain neurochemistry.". European Neuropsychopharmacology (Elsevier) 29: S93. December 2019. doi:10.1016/j.euroneuro.2019.09.164. https://www.researchgate.net/publication/338885595.
- ↑ "TAAR6 mutant mice have changes in the brain serotonin levels and enhanced hypothermic response to serotonin 5-HT1A receptor agonist 8-OH-DPAT". European Neuropsychopharmacology (Elsevier) 53: S212–S213. December 2021. doi:10.1016/j.euroneuro.2021.10.279. https://www.researchgate.net/publication/357424289.
Further reading
- "Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees". Genomics 43 (1): 1–8. July 1997. doi:10.1006/geno.1997.4815. PMID 9226366.
- "NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees". American Journal of Medical Genetics 81 (4): 282–9. July 1998. doi:10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W. PMID 9674972.
- "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America 98 (16): 8966–71. July 2001. doi:10.1073/pnas.151105198. PMID 11459929.
- "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". American Journal of Human Genetics 75 (4): 624–38. October 2004. doi:10.1086/424887. PMID 15329799.
- "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. March 2005. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- "The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23". Molecular Psychiatry 11 (2): 119–21. February 2006. doi:10.1038/sj.mp.4001752. PMID 16189505.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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