Biology:GPR4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.

See also

• Proton-sensing G protein-coupled receptors

Further reading

• "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.". FEBS Lett. 375 (1–2): 121–4. 1996. doi:10.1016/0014-5793(95)01196-L. PMID 7498459. 
• Heiber M; Docherty JM; Shah G; Nguyen, Tuan; Cheng, Regina; Heng, Henry H.Q.; Marchese, Adriano; Tsui, LAP-Chee et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990. 
• Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Lum H; Qiao J; Walter RJ; Huang, F; Subbaiah, PV; Kim, KS; Holian, O (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. doi:10.1152/ajpheart.00359.2003. PMID 12805023. 
• Ludwig MG; Vanek M; Guerini D; Gasser, Jürg A.; Jones, Carol E.; Junker, Uwe; Hofstetter, Hans; Wolf, Romain M. et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature 425 (6953): 93–8. doi:10.1038/nature01905. PMID 12955148. Bibcode: 2003Natur.425...93L. 
• Bektas M; Barak LS; Jolly PS; Liu, Hong; Lynch, Kevin R.; Lacana, Emanuela; Suhr, Ki-Beom; Milstien, Sheldon et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679. 
• Sin WC; Zhang Y; Zhong W; Adhikarakunnathu, Sree; Powers, Scott; Hoey, Tim; An, Songzhu; Yang, Jianxin (2004). "G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers". Oncogene 23 (37): 6299–303. doi:10.1038/sj.onc.1207838. PMID 15221007. 
• Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Kim KS; Ren J; Jiang Y; Ebrahem, Q; Tipps, R; Cristina, K; Xiao, YJ; Qiao, J et al. (2005). "GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine". FASEB J. 19 (7): 819–21. doi:10.1096/fj.04-2988fje. PMID 15857892. 
• Qiao J; Huang F; Naikawadi RP; Kim, KS; Said, T; Lum, H (2006). "Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91–101. doi:10.1152/ajplung.00508.2005. PMID 16461426. 
• Huang F; Mehta D; Predescu S; Kim, Kwang; Lum, Hazel (2007). "A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration". Endothelium 14 (1): 25–34. doi:10.1080/10623320601177288. PMID 17364894. 
• Zou Y; Kim CH; Chung JH; Kim, Ji Y.; Chung, Sang W.; Kim, Mi K.; Im, Dong S.; Lee, Jaewon et al. (2007). "Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4". FEBS J. 274 (10): 2573–84. doi:10.1111/j.1742-4658.2007.05792.x. PMID 17437524. 
• Tobo M; Tomura H; Mogi C; Wang, J; Liu, J; Komachi, M; Damirin, A; Kimura, T et al. (2007). "Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms". Cell. Signal. 19 (8): 1745–53. doi:10.1016/j.cellsig.2007.03.009. PMID 17462861.