Biology:GPR124
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[1][2][3] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4][5][6]
Interactions
GPR124 has been shown to interact with DLG1[7] and is involved in the Wnt/β-catenin signaling pathway along with RECK.[8] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain.[9]
Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.
References
- ↑ "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res 61 (18): 6649–55. September 2001. PMID 11559528.
- ↑ "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. February 2003. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
- ↑ "Entrez Gene: GPR124 G protein-coupled receptor 124". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25960.
- ↑ AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. 2011. ISBN 978-1-4419-7912-4.
- ↑ "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. Nov 2002. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ↑ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. March 2012. doi:10.1038/emboj.2012.26. PMID 22333914.
- ↑ "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene 23 (22): 3889–97. May 2004. doi:10.1038/sj.onc.1207495. PMID 15021905.
- ↑ "Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis". eLife 4: e06489. June 2015. doi:10.7554/eLife.06489. PMID 26051822.
- ↑ Doctor, Katarina Z.; Gilmour, Elizabeth; Recarte, Marilyn; Beatty, Trinity R.; Shifa, Intisar; Stangel, Michaela; Schwisow, Jacob; Leary, Dagmar H. et al. (2023-02-15). "Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses" (in en). Viruses 15 (2): 542. doi:10.3390/v15020542. ISSN 1999-4915. PMID 36851756.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. 2000. doi:10.1093/dnares/7.2.143. PMID 10819331.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.". Oncogene 23 (22): 3889–97. 2004. doi:10.1038/sj.onc.1207495. PMID 15021905.
- "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. 2005. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- "Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.". J. Biol. Chem. 281 (45): 34179–88. 2006. doi:10.1074/jbc.M605291200. PMID 16982628.
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