Biology:Platelet-activating factor receptor
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor.[1][2] It is encoded in the human by the PTAFR gene.
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][3] Its pathogenetic role in chronic kidney failure has also been reported recently.[4]
Ligands
Agonists
- Platelet activating factor
Antagonists
- Apafant (WEB-2086)
- Israpafant (Y-24180)
- Lexipafant
- Rupatadine
References
- ↑ "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics 13 (3): 832–4. 1992. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
- ↑ "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68-69: 599–609. 2002. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
- ↑ "Entrez Gene: PTAFR platelet-activating factor receptor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5724.
- ↑ Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.". Lab. Invest. 94 (4): 455–466. doi:10.1038/labinvest.2013.155. PMID 24492283.
Further reading
- Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms.". FASEB J. 6 (6): 2296–301. doi:10.1096/fasebj.6.6.1312046. PMID 1312046.
- "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.". Biochem. Biophys. Res. Commun. 189 (2): 617–24. 1993. doi:10.1016/0006-291X(92)92245-S. PMID 1281995.
- "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.". Genomics 13 (3): 832–4. 1992. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
- "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.". J. Biol. Chem. 267 (13): 9101–6. 1992. doi:10.1016/S0021-9258(19)50394-5. PMID 1374385.
- "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.". Biochem. Biophys. Res. Commun. 180 (1): 105–11. 1991. doi:10.1016/S0006-291X(05)81261-6. PMID 1656963.
- "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.". J. Biol. Chem. 266 (30): 20400–5. 1991. doi:10.1016/S0021-9258(18)54936-X. PMID 1657923.
- "Receptor-Effector Coupling in Platelets: Roles of Guanine Nucleotides". Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology. 192. 1985. pp. 265–80. doi:10.1007/978-1-4615-9442-0_19. ISBN 978-1-4615-9444-4.
- Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.". Immunology 52 (1): 169–74. PMID 6325330.
- "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.". Nature 377 (6548): 435–8. 1995. doi:10.1038/377435a0. PMID 7566121. Bibcode: 1995Natur.377..435C.
- "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.". Biochem. J.. 305 ( Pt 3) (3): 829–35. 1995. doi:10.1042/bj3050829. PMID 7848283.
- "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.". Eur. J. Biochem. 221 (1): 211–8. 1994. doi:10.1111/j.1432-1033.1994.tb18731.x. PMID 8168510.
- "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. 1993. doi:10.1165/ajrcmb/8.3.240. PMID 8383507.
- "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.". FEBS Lett. 322 (2): 129–34. 1993. doi:10.1016/0014-5793(93)81552-B. PMID 8387031.
- "Isolation and properties of platelet-activating factor receptor cDNAs.". Journal of Lipid Mediators 6 (1–3): 163–8. 1993. PMID 8395240.
- "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.". J. Immunol. 157 (9): 4126–32. 1996. doi:10.4049/jimmunol.157.9.4126. PMID 8892648.
- "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 72 (2–3): 205–7. 1997. doi:10.1159/000134190. PMID 8978777.
- "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.". FEBS Lett. 402 (2–3): 203–8. 1997. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196.
- "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.". FASEB J. 12 (10): 831–43. 1998. doi:10.1096/fasebj.12.10.831. PMID 9657523.
- "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. 1999. doi:10.1038/10290. PMID 10391209.
External links
- "Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1348.
- platelet+activating+factor+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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