Biology:OPN1SW
 Generic protein structure example |
Blue-sensitive opsin is a protein that in humans is encoded by the OPN1SW gene.[1][2][3] The OPN1SW gene provides instructions for making a protein that is essential for normal color vision. This protein is found in the retina, which is the light-sensitive tissue at the back of the eye.[4]
The OPN1SW gene provides instructions for making an opsin pigment that is more sensitive to light in the blue/violet part of the visible spectrum (short-wavelength light). Cones with this pigment are called short-wavelength-sensitive or S cones.[4] In response to light, the photopigment triggers a series of chemical reactions within an S cone. These reactions ultimately alter the cell's electrical charge, generating a signal that is transmitted to the brain. The brain combines input from all three types of cones to produce normal color vision.[4]
See also
References
- ↑ "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments". Science 232 (4747): 193–202. Apr 1986. doi:10.1126/science.2937147. PMID 2937147. Bibcode: 1986Sci...232..193N.
- ↑ "Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32". Hum Genet 93 (1): 79–80. Feb 1994. doi:10.1007/bf00218919. PMID 8270261.
- ↑ "Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=611.
- ↑ 4.0 4.1 4.2 "OPN1SW gene: MedlinePlus Genetics". https://medlineplus.gov/genetics/gene/opn1sw/.
Further reading
- "Molecular biology of the visual pigments". Vision Res. 26 (12): 1881–95. 1987. doi:10.1016/0042-6989(86)90115-X. PMID 3303660.
- "Color vision". Ophthalmology Clinics of North America 16 (2): 179–203. 2003. doi:10.1016/S0896-1549(03)00004-X. PMID 12809157.
- "Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment". Am. J. Hum. Genet. 51 (2): 444–6. 1992. PMID 1386496.
- Weitz CJ; Miyake Y; Shinzato K et al. (1992). "Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin". Am. J. Hum. Genet. 50 (3): 498–507. PMID 1531728.
- "Design, chemical synthesis, and expression of genes for the three human color vision pigments". Biochemistry 30 (48): 11367–72. 1992. doi:10.1021/bi00112a002. PMID 1742276.
- "Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity". Science 244 (4902): 331–4. 1989. doi:10.1126/science.2565599. PMID 2565599. Bibcode: 1989Sci...244..331S.
- Nathans J; Piantanida TP; Eddy RL et al. (1986). "Molecular genetics of inherited variation in human color vision". Science 232 (4747): 203–10. doi:10.1126/science.3485310. PMID 3485310. Bibcode: 1986Sci...232..203N.
- "Sequences and evolution of human and squirrel monkey blue opsin genes". J. Mol. Evol. 44 (4): 378–82. 1997. doi:10.1007/PL00006157. PMID 9089077. Bibcode: 1997JMolE..44..378S.
- Scherer SW; Cheung J; MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. Bibcode: 2003Sci...300..767S.
- "A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect". Vis. Neurosci. 23 (3–4): 403–9. 2006. doi:10.1017/S0952523806233169. PMID 16961973.
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