Biology:Neurotensin receptor 2
 Generic protein structure example |
Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]
Function
The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in the brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3]
See also
References
- ↑ "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters 386 (2–3): 91–4. May 1996. doi:10.1016/0014-5793(96)00397-3. PMID 8647296.
- ↑ "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology 360 (2–3): 265–72. Nov 1998. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
- ↑ 3.0 3.1 "Entrez Gene: NTSR2 neurotensin receptor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23620.
Further reading
- "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences 20 (7): 302–9. Jul 1999. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
- "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". The Journal of Neuroscience 16 (18): 5613–20. Sep 1996. doi:10.1523/jneurosci.16-18-05613.1996. PMID 8795617.
- "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". The Journal of Investigative Dermatology 117 (3): 687–93. Sep 2001. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
- "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". Journal of Cell Science 115 (Pt 1): 165–73. Jan 2002. doi:10.1242/jcs.115.1.165. PMID 11801734.
- "Expression of neurotensin receptors in human corneal keratocytes". Investigative Ophthalmology & Visual Science 43 (6): 1765–71. Jun 2002. PMID 12036977.
- "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". European Journal of Pharmacology 442 (3): 179–86. May 2002. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.
- "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications 295 (2): 482–8. Jul 2002. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
- "Common structural basis for constitutive activity of the ghrelin receptor family". The Journal of Biological Chemistry 279 (51): 53806–17. Dec 2004. doi:10.1074/jbc.M407676200. PMID 15383539.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links
- "Neurotensin Receptors: NTS2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3005.
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