Biology:GPR151
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene.[1][2] It is weakly activated by galanin, but its endogenous ligand remains unknown. Studies have suggested GPR151 may play a role in several clinically significant processes such as inflammation, pain perception and reward-seeking behavior as well as hepatic glucose production, but further research into its function has been limited so far by a lack of selective agonists and antagonists for this receptor, with most research to date using knockout mice.[3][4][5][6][7]
References
- ↑ "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America 100 (8): 4903–4908. April 2003. doi:10.1073/pnas.0230374100. PMID 12679517. Bibcode: 2003PNAS..100.4903V.
- ↑ "Entrez Gene: GPR151 G protein-coupled receptor 151". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=134391.
- ↑ "Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain". Molecular and Cellular Neurosciences 78: 35–40. January 2017. doi:10.1016/j.mcn.2016.11.010. PMID 27913310.
- ↑ "The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula". Scientific Reports 12 (1). November 2022. doi:10.1038/s41598-022-24395-z. PMID 36424418. Bibcode: 2022NatSR..1220234A.
- ↑ "G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis". Nature Communications 13 (1). December 2022. doi:10.1038/s41467-022-35069-9. PMID 36456565. Bibcode: 2022NatCo..13.7408B.
- ↑ "Circadian disruption upon painful peripheral nerve injury in mice: Temporal effects on transcriptome in pain-regulating sensory tissues". Neurobiology of Disease 211. July 2025. doi:10.1016/j.nbd.2025.106934. PMID 40324566.
- ↑ "The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological Significance". ACS Chemical Neuroscience 16 (9): 1639–1646. May 2025. doi:10.1021/acschemneuro.4c00780. PMID 40295925.
Further reading
- "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1–3): 97–101. June 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. Bibcode: 2002FEBSL.520...97T.
- "Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors". Neuropharmacology 46 (8): 1114–1120. June 2004. doi:10.1016/j.neuropharm.2004.02.004. PMID 15111018.
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