Biology:OPN1MW

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Green-sensitive opsin is a protein that in humans is encoded by the OPN1MW gene. The number of genes that code for green-sensitive opsin varies from person to person, but in the reference genome (GRCh38) there are three: OPN1MW, OPN1MW2 and OPN1MW3, all which code for identical proteinsd.

The OPN1MW gene provides instructions for making an opsin pigment that is more sensitive to light in the middle of the visible spectrum (yellow/green light).

See also

• Opsin
• OPN1LW
• OPN1SW

Further reading

• "Molecular biology of the visual pigments". Vision Res. 26 (12): 1881–95. 1987. doi:10.1016/0042-6989(86)90115-X. PMID 3303660. 
• "Defective colour vision associated with a missense mutation in the human green visual pigment gene". Nat. Genet. 1 (4): 251–6. 1993. doi:10.1038/ng0792-251. PMID 1302020. 
• "Analysis of fusion gene and encoded photopigment of colour-blind humans". Nature 342 (6250): 679–82. 1990. doi:10.1038/342679a0. PMID 2574415. 
• "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments". Science 232 (4747): 193–202. 1986. doi:10.1126/science.2937147. PMID 2937147. Bibcode: 1986Sci...232..193N. 
• "Rod photoreceptor neurite sprouting in retinitis pigmentosa". J. Neurosci. 15 (8): 5429–38. 1995. doi:10.1523/JNEUROSCI.15-08-05429.1995. PMID 7643192. 
• "A new mechanism in blue cone monochromatism". Hum. Genet. 98 (4): 403–8. 1996. doi:10.1007/s004390050229. PMID 8792812. 
• "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin". Nature 383 (6601): 637–40. 1996. doi:10.1038/383637a0. PMID 8857542. Bibcode: 1996Natur.383..637F. 
• "Large-scale production and purification of the human green cone pigment: characterization of late photo-intermediates". Biochem. J. 330 (3): 1201–8. 1998. doi:10.1042/bj3301201. PMID 9494086. 
• "Regional expression of disease-related genes in human and monkey retina". Mol. Vis. 4: 24. 1998. PMID 9815288. 
• "Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype". Nat. Genet. 22 (1): 90–3. 1999. doi:10.1038/8798. PMID 10319869. 
• "Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies". Biochem. Biophys. Res. Commun. 294 (2): 205–9. 2002. doi:10.1016/S0006-291X(02)00458-8. PMID 12051694. Bibcode: 2002BBRC..294..205U. 
• "GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina". J. Neurosci. 23 (14): 6152–60. 2003. doi:10.1523/JNEUROSCI.23-14-06152.2003. PMID 12853434. 
• "Abnormal distribution of red/green cone opsins in a patient with an autosomal dominant cone dystrophy". Ophthalmic Genet. 26 (2): 69–76. 2005. doi:10.1080/13816810590968041. PMID 16020309. 

External links

• GeneReviews/NIH/NCBI/UW entry on Red-Green Color Vision Defects