Biology:Somatostatin receptor 3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.

See also

• Somatostatin receptor

Further reading

• "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase". Molecular Endocrinology 6 (12): 2136–42. December 1992. doi:10.1210/mend.6.12.1337145. PMID 1337145. 
• "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America 89 (1): 251–5. January 1992. doi:10.1073/pnas.89.1.251. PMID 1346068. Bibcode: 1992PNAS...89..251Y. 
• "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides". FEBS Letters 321 (2–3): 279–84. April 1993. doi:10.1016/0014-5793(93)80124-D. PMID 8097479. 
• "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Molecular Pharmacology 45 (4): 587–90. April 1994. PMID 8183236. 
• "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters 331 (1–2): 53–9. September 1993. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. 
• "Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3". Molecular Endocrinology 10 (12): 1688–96. December 1996. doi:10.1210/mend.10.12.8961277. PMID 8961277. 
• "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications 232 (1): 157–63. March 1997. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
• "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". The Journal of Clinical Endocrinology and Metabolism 82 (6): 1857–62. June 1997. doi:10.1210/jcem.82.6.4013. PMID 9177396. 
• "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics 42 (3): 499–506. June 1997. doi:10.1006/geno.1997.4763. PMID 9205124. 
• "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization". The Journal of Biological Chemistry 272 (38): 23769–74. September 1997. doi:10.1074/jbc.272.38.23769. PMID 9295322. 
• "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. December 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D. 
• "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism 86 (5): 2161–9. May 2001. doi:10.1210/jcem.86.5.7489. PMID 11344221. 
• "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clinical and Experimental Immunology 125 (1): 71–9. July 2001. doi:10.1046/j.1365-2249.2001.01577.x. PMID 11472428. 
• "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica 26 (3): 175–9. September 2001. PMID 11753241. 
• "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv 440 (5): 461–75. May 2002. doi:10.1007/s00428-002-0609-x. PMID 12021920. 
• "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". American Journal of Physiology. Endocrinology and Metabolism 283 (5): E1056-66. November 2002. doi:10.1152/ajpendo.00205.2001. PMID 12376335. 
• "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". The Journal of Clinical Endocrinology and Metabolism 87 (11): 5125–9. November 2002. doi:10.1210/jc.2002-020790. PMID 12414882. 
• "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urologic Oncology 7 (3): 91–8. 2002. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541. 

External links

• "Somatostatin Receptors: sst₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2437. 
• somatostatin+receptor+3 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.