Biology:GPRC5A
 Generic protein structure example |
Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.[1][2] This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1);[3] two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1).[1] Its encoded protein was later named Retinoic acid-induced protein 3.
Function
This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[2] Tryptamine and other indole related chemicals produced by gut microflora bind and activate the receptor.[4]
Post transcriptional regulation
GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.[5]
Clinical significance
GPRC5A is dysregulated in many human cancers and in other diseases.[6]
See also
References
- ↑ 1.0 1.1 "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. 1998. doi:10.1074/jbc.273.52.35008. PMID 9857033.
- ↑ 2.0 2.1 "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9052.
- ↑ "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand) 42 (5): 797–804. 1996. PMID 8832110.
- ↑ Goldstein, Daniel R. (2004). "Toll-like receptors and other links between innate and acquired alloimmunity". Current Opinion in Immunology 16 (5): 538–544. doi:10.1016/j.coi.2004.08.001. PMID 15341996.
- ↑ "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA 20 (9): 1431–9. 2014. doi:10.1261/rna.045757.114. PMID 24984703.
- ↑ "The emerging roles of GPRC5A in diseases". Oncoscience 1 (12): 765–76. 2014. doi:10.18632/oncoscience.104. PMID 25621293.
Further reading
- "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand) 42 (5): 797–804. 1996. PMID 8832110.
- "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics 65 (2): 121–8. 2000. doi:10.1006/geno.2000.6164. PMID 10783259.
- "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics 67 (1): 8–18. 2000. doi:10.1006/geno.2000.6226. PMID 10945465.
- "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid". Genomics 83 (2): 270–80. 2004. doi:10.1016/S0888-7543(03)00237-4. PMID 14706456.
- "Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target". J. Biol. Chem. 280 (13): 12935–43. 2005. doi:10.1074/jbc.M409901200. PMID 15659406.
- "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics 4 (9): 1240–50. 2005. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
- "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression". Biochem. Biophys. Res. Commun. 351 (1): 185–91. 2006. doi:10.1016/j.bbrc.2006.10.016. PMID 17055459.
- "Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene". Arch. Biochem. Biophys. 687: 108375. 2020. doi:10.1016/j.abb.2020.108375. PMID 32339486.
External links
- "GPRC5 Receptors: RAIG1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2959.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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