Biology:GPR25
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.[1][2]
Structure
It is a member of the G protein-coupled receptor (GPCR) family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.[3]
Tissue distribution
GPR25 expression is largely restricted to lymphocytes and natural killer (NK) cells.[3]
Function
It has been identified as the receptor for the chemokine-like protein CXCL17.[3]
References
- ↑ "Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1". Biochemical and Biophysical Research Communications 230 (1): 69–72. Feb 1997. doi:10.1006/bbrc.1996.5828. PMID 9020062.
- ↑ "Entrez Gene: GPR25 G protein-coupled receptor 25". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2848.
- ↑ 3.0 3.1 3.2 "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature 635 (8039): 736–745. 21 November 2024. doi:10.1038/s41586-024-08043-2. PMID 39293486. Bibcode: 2024Natur.635..736O.
Further reading
- "A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study.". American Journal of Hypertension 20 (4): 398–402. Apr 2007. doi:10.1016/j.amjhyper.2006.10.001. PMID 17386346.
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