Biology:FZD5

Generic protein structure example

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.

See also

• Frizzled

Further reading

• "A member of the Frizzled protein family mediating axis induction by Wnt-5A.". Science 275 (5306): 1652–4. 1997. doi:10.1126/science.275.5306.1652. PMID 9054360. https://zenodo.org/record/1231094. 
• "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. 1997. doi:10.1073/pnas.94.13.6770. PMID 9192640. Bibcode: 1997PNAS...94.6770F. 
• "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. 1998. doi:10.1073/pnas.95.17.10164. PMID 9707618. Bibcode: 1998PNAS...9510164T. 
• "LDL-receptor-related proteins in Wnt signal transduction.". Nature 407 (6803): 530–5. 2000. doi:10.1038/35035117. PMID 11029007. Bibcode: 2000Natur.407..530T. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.". Biochem. Biophys. Res. Commun. 286 (4): 771–8. 2001. doi:10.1006/bbrc.2001.5430. PMID 11520064. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.". J. Rheumatol. 31 (9): 1874–5. 2004. PMID 15338479. 
• "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. 2004. doi:10.1080/13816810490514270. PMID 15370539. 
• "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.". Biochem. Biophys. Res. Commun. 328 (2): 533–9. 2005. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380. 
• "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H. 
• "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.". Blood 108 (3): 965–73. 2006. doi:10.1182/blood-2005-12-5046. PMID 16601243. 
• "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.". Dev. Cell 11 (2): 213–23. 2006. doi:10.1016/j.devcel.2006.07.003. PMID 16890161. 
• "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.". Int. J. Oncol. 30 (3): 751–5. 2007. doi:10.3892/ijo.30.3.751. PMID 17273778. 

External links

• "Frizzled Receptors: FZD₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3063. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.