Biology:CELSR1
 Generic protein structure example |
Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.[1][2]
Function
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[2]
See also
References
- ↑ "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter". Genomics 45 (1): 97–104. Nov 1997. doi:10.1006/geno.1997.4892. PMID 9339365. https://pure.uva.nl/ws/files/3045332/3179_29691y.pdf.
- ↑ 2.0 2.1 "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620.
External links
- Human CELSR1 genome location and CELSR1 gene details page in the UCSC Genome Browser.
- Human ME2 genome location and ME2 gene details page in the UCSC Genome Browser.
Further reading
- "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. 2000. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. 1999. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
- "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. 2000. doi:10.1073/pnas.060027397. PMID 10716726.
- Ghosh A (2000). "Dentritic [sic] growth: don't go says flamingo". Neuron 28 (1): 3–4. doi:10.1016/S0896-6273(00)00076-3. PMID 11086974.
- "Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family". Psychiatr. Genet. 11 (4): 197–200. 2002. doi:10.1097/00041444-200112000-00003. PMID 11807409.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia". Psychiatr. Genet. 13 (2): 103–6. 2004. doi:10.1097/01.ypg.0000057486.14812.03. PMID 12782967.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell 122 (1): 33–43. 2005. doi:10.1016/j.cell.2005.05.008. PMID 16009131.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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