Biology:TAAR8
From HandWiki
Short description: Protein and coding gene in humans
 Generic protein structure example |
Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene.[1][2][3] In humans, TAAR8 is the only trace amine-associated receptor that is known to be Gi/o-coupled.[4]
In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.[5]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM[3]
See also
References
- ↑ "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. September 2001. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- ↑ "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. March 2005. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- ↑ 3.0 3.1 "Entrez Gene: TAAR8 trace amine associated receptor 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551.
- ↑ "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". International Journal of Molecular Sciences 15 (11): 20638–55. November 2014. doi:10.3390/ijms151120638. PMID 25391046.
- ↑ "Identifying human diamine sensors for death related putrescine and cadaverine molecules". PLOS Computational Biology 14 (1): e1005945. January 2018. doi:10.1371/journal.pcbi.1005945. PMID 29324768. Bibcode: 2018PLSCB..14E5945I.
Further reading
- "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America 98 (16): 8966–71. July 2001. doi:10.1073/pnas.151105198. PMID 11459929. Bibcode: 2001PNAS...98.8966B.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
