Biology:EMR3
 Generic protein structure example |
EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.[1][2] EMR3 is a member of the adhesion GPCR family.[3][4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]
EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[6] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[7] Mice, next to Emr2, lack the Emr3 gene.[8]
Function
The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[9]
Ligands
A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[7]
References
- ↑ "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry 276 (22): 18863–70. Jun 2001. doi:10.1074/jbc.M101147200. PMID 11279179.
- ↑ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288.
- ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
- ↑ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science Signaling 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165.
- ↑ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. Mar 2012. doi:10.1038/emboj.2012.26. PMID 22333914.
- ↑ "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". Journal of Leukocyte Biology 81 (2): 440–8. Feb 2007. doi:10.1189/jlb.0406276. PMID 17108056.
- ↑ 7.0 7.1 "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry 276 (22): 18863–70. Jun 2001. doi:10.1074/jbc.M101147200. PMID 11279179.
- ↑ "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal 20 (14): 2582–4. Dec 2006. doi:10.1096/fj.06-6500fje. PMID 17068111.
- ↑ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658.
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