Chemistry:Foslevodopa

From HandWiki

Foslevodopa is a medication which acts as a prodrug for levodopa, originally invented in the 1980s but not developed for medical use at that time.[1] It is approved for use in a subcutaneous infusion as a fixed-dose combination with foscarbidopa for the treatment of Parkinson's disease, under the brand name Vyalev.[2][3]

References

  1. "Phosphorylated mixed isomers of L-dopa increase melanin content in skins of Skh-2 pigmented hairless mice". Pigment Cell Research 1 (3): 137–142. 1987. doi:10.1111/j.1600-0749.1987.tb00404.x. PMID 3149738. 
  2. "Subcutaneous Levodopa: A New Engine for the Vintage Molecule". Neurology and Therapy 13 (4): 1055–1068. August 2024. doi:10.1007/s40120-024-00635-4. PMID 38874708. 
  3. "Continuous subcutaneous foslevodopa/foscarbidopa infusion for the treatment of motor fluctuations in Parkinson's disease: Considerations for initiation and maintenance". Clinical Parkinsonism & Related Disorders 10. 2024. doi:10.1016/j.prdoa.2024.100239. PMID 38419617.