Biology:GPR101: Difference between revisions
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene.[1][2]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[2]
Clinical significance
A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.[3]
References
- ↑ "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. Sep 2001. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- ↑ 2.0 2.1 "Entrez Gene: GPR101 G protein-coupled receptor 101". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83550.
- ↑ "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. 371 (25): 2363–74. 2014. doi:10.1056/NEJMoa1408028. PMID 25470569.
Further reading
- "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
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