Biology:GPR114

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.[1][2][3] GPR114 is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[7]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein.[8]

References

  1. ↑ "Entrez Gene: GPR114 G protein-coupled receptor 114". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221188. 
  2. ↑ "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. Nov 2002. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ↑ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  4. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4. 
  5. ↑ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science Signaling 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. 
  6. ↑ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. Mar 2012. doi:10.1038/emboj.2012.26. PMID 22333914. 
  7. ↑ "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. Apr 2015. doi:10.1124/pr.114.009647. PMID 25713288. 
  8. ↑ "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters 586 (8): 1214–9. Apr 2012. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. 

External links



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