Biology:Somatostatin receptor 3
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.[1][2]
Function
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.[2]
See also
References
- ↑ "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449–52. February 1993. doi:10.1006/geno.1993.1088. PMID 8449518.
- ↑ 2.0 2.1 "Entrez Gene: SSTR3 somatostatin receptor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6753.
Further reading
- "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase". Molecular Endocrinology 6 (12): 2136–42. December 1992. doi:10.1210/mend.6.12.1337145. PMID 1337145.
- "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America 89 (1): 251–5. January 1992. doi:10.1073/pnas.89.1.251. PMID 1346068. Bibcode: 1992PNAS...89..251Y.
- "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides". FEBS Letters 321 (2–3): 279–84. April 1993. doi:10.1016/0014-5793(93)80124-D. PMID 8097479.
- "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Molecular Pharmacology 45 (4): 587–90. April 1994. PMID 8183236.
- "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters 331 (1–2): 53–9. September 1993. doi:10.1016/0014-5793(93)80296-7. PMID 8405411.
- "Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3". Molecular Endocrinology 10 (12): 1688–96. December 1996. doi:10.1210/mend.10.12.8961277. PMID 8961277.
- "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications 232 (1): 157–63. March 1997. doi:10.1006/bbrc.1997.6252. PMID 9125122.
- "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". The Journal of Clinical Endocrinology and Metabolism 82 (6): 1857–62. June 1997. doi:10.1210/jcem.82.6.4013. PMID 9177396.
- "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics 42 (3): 499–506. June 1997. doi:10.1006/geno.1997.4763. PMID 9205124.
- "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization". The Journal of Biological Chemistry 272 (38): 23769–74. September 1997. doi:10.1074/jbc.272.38.23769. PMID 9295322.
- "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. December 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism 86 (5): 2161–9. May 2001. doi:10.1210/jcem.86.5.7489. PMID 11344221.
- "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clinical and Experimental Immunology 125 (1): 71–9. July 2001. doi:10.1046/j.1365-2249.2001.01577.x. PMID 11472428.
- "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica 26 (3): 175–9. September 2001. PMID 11753241.
- "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv 440 (5): 461–75. May 2002. doi:10.1007/s00428-002-0609-x. PMID 12021920.
- "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". American Journal of Physiology. Endocrinology and Metabolism 283 (5): E1056-66. November 2002. doi:10.1152/ajpendo.00205.2001. PMID 12376335.
- "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". The Journal of Clinical Endocrinology and Metabolism 87 (11): 5125–9. November 2002. doi:10.1210/jc.2002-020790. PMID 12414882.
- "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urologic Oncology 7 (3): 91–8. 2002. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541.
External links
- "Somatostatin Receptors: sst3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2437.
- somatostatin+receptor+3 at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/Somatostatin receptor 3.
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