Biology:GNRHR

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

See also

• Gonadotropin-releasing hormone receptor

Further reading

• "Follistatins: more than follicle-stimulating hormone suppressing proteins.". Mol. Cell. Endocrinol. 91 (1–2): 1–11. 1993. doi:10.1016/0303-7207(93)90248-I. PMID 8472841. 
• "Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions.". Rev. Reprod. 2 (2): 113–20. 1998. doi:10.1530/ror.0.0020113. PMID 9414473. 
• "The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans.". Frontiers in Neuroendocrinology 24 (4): 279–95. 2004. doi:10.1016/j.yfrne.2003.10.003. PMID 14726258. 
• "Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function.". Semin. Reprod. Med. 25 (5): 368–78. 2007. doi:10.1055/s-2007-984743. PMID 17710733. 
• "Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor.". Biochem. Biophys. Res. Commun. 189 (1): 289–95. 1992. doi:10.1016/0006-291X(92)91556-6. PMID 1333190. 
• "The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary.". Mol. Cell. Endocrinol. 106 (1–2): 145–9. 1995. doi:10.1016/0303-7207(94)90196-1. PMID 7534732. 
• "Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization.". Mamm. Genome 6 (4): 309–10. 1995. doi:10.1007/BF00352431. PMID 7613048. 
• "The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals.". Mol. Cell. Endocrinol. 107 (2): R1–8. 1995. doi:10.1016/0303-7207(94)03460-B. PMID 7768323. 
• "The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment.". Mol. Cell. Endocrinol. 103 (1–2): R1–6. 1994. doi:10.1016/0303-7207(94)90087-6. PMID 7958384. 
• "Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor.". Mol. Endocrinol. 11 (9): 1305–18. 1997. doi:10.1210/mend.11.9.9966. PMID 9259321. 
• Kakar SS (1997). "Molecular structure of the human gonadotropin-releasing hormone receptor gene.". Eur. J. Endocrinol. 137 (2): 183–92. doi:10.1530/eje.0.1370183. PMID 9272108. 
• "A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor.". N. Engl. J. Med. 337 (22): 1597–602. 1997. doi:10.1056/NEJM199711273372205. PMID 9371856. 
• "Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism.". Nat. Genet. 18 (1): 14–5. 1998. doi:10.1038/ng0198-14. PMID 9425890. 
• "The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred.". J. Clin. Endocrinol. Metab. 84 (2): 567–72. 1999. doi:10.1210/jcem.84.2.5449. PMID 10022417. 
• "Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration.". J. Clin. Endocrinol. Metab. 84 (3): 990–6. 1999. doi:10.1210/jcem.84.3.5518. PMID 10084584. 
• "Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene.". Eur. J. Endocrinol. 140 (6): 561–9. 1999. doi:10.1530/eje.0.1400561. PMID 10366411. 
• "Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor.". J. Clin. Endocrinol. Metab. 84 (10): 3811–6. 1999. doi:10.1210/jcem.84.10.6042. PMID 10523035. 

External links

• "Gonadotrophin-Releasing Hormone Receptors: GnRH receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3035. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.