Biology:S1PR4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₄.

Function

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.

Evolution

Paralogues to S1PR4 Gene

• S1PR5
• S1PR3
• S1PR1
• S1PR2
• LPAR2
• LPAR1
• LPAR3
• CNR1
• GPR6
• CNR2
• GPR3
• GPR12
• MC4R
• MC5R
• MC3R
• MC2R
• MC1R
• GPR119

See also

• Lysophospholipid receptor

Further reading

• "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.". Genomics 53 (2): 164–9. 1998. doi:10.1006/geno.1998.5491. PMID 9790765. 
• "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.". Biochem. Biophys. Res. Commun. 268 (2): 583–9. 2000. doi:10.1006/bbrc.2000.2162. PMID 10679247. 
• "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.". Blood 95 (8): 2624–9. 2000. doi:10.1182/blood.V95.8.2624. PMID 10753843. 
• "Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.". FASEB J. 16 (6): 625–7. 2002. doi:10.1096/fj.01-0625fje. PMID 11919175. 
• "Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.". Eur. J. Immunol. 32 (7): 1856–64. 2002. doi:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604. 
• "Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.". Biochem. Biophys. Res. Commun. 297 (3): 600–6. 2002. doi:10.1016/S0006-291X(02)02237-4. PMID 12270137. 
• "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.". FEBS Lett. 531 (1): 99–102. 2002. doi:10.1016/S0014-5793(02)03409-9. PMID 12401211. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.". J. Invest. Dermatol. 120 (4): 693–700. 2003. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. 
• "The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13.". J. Cell. Biochem. 89 (3): 507–19. 2003. doi:10.1002/jcb.10537. PMID 12761884. 
• "Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm.". International Journal of Oral and Maxillofacial Surgery 32 (3): 337–8. 2003. doi:10.1054/ijom.2003.0364. PMID 12767884. 
• "A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.". BMC Biochem. 5: 12. 2005. doi:10.1186/1471-2091-5-12. PMID 15298705. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 

External links

• "Lysophospholipid Receptors: S₁P₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2996. 
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.