Biology:Frizzled-6
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.[1][2][3]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[3] Fz-6 is believed to be the receptor for the WNT4 ligand.[4]
Interactions
Fz-6 has been shown to interact with secreted frizzled-related protein 1.[5]
References
- ↑ "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications 243 (2): 622–7. Feb 1998. doi:10.1006/bbrc.1998.8143. PMID 9480858.
- ↑ "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry 279 (15): 14879–88. Apr 2004. doi:10.1074/jbc.M306421200. PMID 14747478.
- ↑ 3.0 3.1 "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8323.
- ↑ "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research 298 (2): 369–87. Aug 2004. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686.
- ↑ "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry 274 (23): 16180–7. Jun 1999. doi:10.1074/jbc.274.23.16180. PMID 10347172.
Further reading
- "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". The Journal of Biological Chemistry 271 (8): 4468–76. Feb 1996. doi:10.1074/jbc.271.8.4468. PMID 8626800.
- "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America 94 (13): 6770–5. Jun 1997. doi:10.1073/pnas.94.13.6770. PMID 9192640. Bibcode: 1997PNAS...94.6770F.
- "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry 274 (23): 16180–7. Jun 1999. doi:10.1074/jbc.274.23.16180. PMID 10347172.
- "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics 25 (2): 81–90. Jun 2004. doi:10.1080/13816810490514270. PMID 15370539.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. Jan 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biological Chemistry 388 (5): 457–65. May 2007. doi:10.1515/BC.2007.059. PMID 17516841.
External links
- "Frizzled Receptors: FZD6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3064.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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