Biology:S1PR3

Short description: Protein and coding gene in humans

Generic protein structure example

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.

Function

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.

Evolution

Paralogues to S1PR3 Gene

• S1PR1
• S1PR5
• S1PR2
• S1PR4
• LPAR1
• LPAR3
• LPAR2
• CNR1
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• GPR3
• MC3R
• MC2R
• GPR119
• MC1R

See also

• Lysophospholipid receptor

Further reading

• "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905 (1): 16–24. 2000. doi:10.1111/j.1749-6632.2000.tb06534.x. PMID 10818438. Bibcode: 2000NYASA.905...16H. 
• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905 (1): 54–60. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. Bibcode: 2000NYASA.905...54S. 
• "Phospholipid growth factors and corneal wound healing.". Ann. N. Y. Acad. Sci. 905 (1): 142–58. 2000. doi:10.1111/j.1749-6632.2000.tb06546.x. PMID 10818450. Bibcode: 2000NYASA.905..142W. 
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348. 
• "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.". Mol. Pharmacol. 49 (6): 956–61. 1996. PMID 8649355. 
• "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.". Biochem. Biophys. Res. Commun. 227 (2): 608–14. 1996. doi:10.1006/bbrc.1996.1553. PMID 8878560. 
• "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279–82. 1998. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733. 
• "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.". J. Biol. Chem. 274 (8): 4626–32. 1999. doi:10.1074/jbc.274.8.4626. PMID 9988698. 
• "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway.". Blood 93 (9): 2984–90. 1999. doi:10.1182/blood.V93.9.2984. PMID 10216094. 
• "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. 1999. doi:10.1074/jbc.274.27.18997. PMID 10383399. 
• "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. 1999. doi:10.1074/jbc.274.39.27351. PMID 10488065. 
• "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.". Cancer Res. 59 (20): 5370–5. 1999. PMID 10537322. 
• "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell 99 (3): 301–12. 1999. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146. 
• "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.". J. Biol. Chem. 275 (1): 288–96. 2000. doi:10.1074/jbc.275.1.288. PMID 10617617. 
• "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.". Arch. Biochem. Biophys. 375 (1): 69–77. 2000. doi:10.1006/abbi.1999.1589. PMID 10683250. 
• "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. 2000. doi:10.1152/ajpcell.2000.278.3.C612. PMID 10712250. 
• "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.". Biochem. J. 348 (1): 71–6. 2000. doi:10.1042/0264-6021:3480071. PMID 10794715. 

External links

• "Lysophospholipid Receptors: S₁P₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2995. 
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.