Biology:GPR182
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Short description: Protein-coding gene in humans
 Generic protein structure example |
GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.[1]
When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.[2] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).[3]
It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.[4]
References
- ↑ "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–4908. April 2003. doi:10.1073/pnas.0230374100. PMID 12679517. Bibcode: 2003PNAS..100.4903V.
- ↑ "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. November 1997. doi:10.1006/bbrc.1997.7631. PMID 9367907.
- ↑ "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. March 1998. doi:10.1006/bbrc.1998.8349. PMID 9535752.
- ↑ "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature 393 (6683): 333–339. May 1998. doi:10.1038/30666. PMID 9620797. Bibcode: 1998Natur.393..333M.
Further reading
- "Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential". Heart Disease (Hagerstown, Md.) 2 (3): 259–65. 2002. PMID 11728267.
- Mukoyama M; Sugawara A; Nagae T et al. (2002). "Role of adrenomedullin and its receptor system in renal pathophysiology". Peptides 22 (11): 1925–1931. doi:10.1016/S0196-9781(01)00525-3. PMID 11754983.
- "The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review)". Int. J. Mol. Med. 9 (5): 443–9. 2002. doi:10.3892/ijmm.9.5.443. PMID 11956648.
- "Receptors for adrenomedullin in human vascular endothelial cells". Eur. J. Pharmacol. 289 (2): 383–385. 1995. doi:10.1016/0922-4106(95)90117-5. PMID 7621913.
- "Adrenomedullin receptor expression in human lung and in pulmonary tumors". J. Histochem. Cytochem. 45 (2): 159–64. 1997. doi:10.1177/002215549704500202. PMID 9016306.
- "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. 1997. doi:10.1006/bbrc.1997.7631. PMID 9367907.
- Martínez A; Elsasser TH; Muro-Cacho C et al. (1997). "Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument". Endocrinology 138 (12): 5597–5604. doi:10.1210/endo.138.12.5622. PMID 9389548.
- Kennedy SP; Sun D; Oleynek JJ et al. (1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID 9535752.
- Jiménez N; Calvo A; Martínez A et al. (1999). "Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate". J. Histochem. Cytochem. 47 (9): 1167–78. doi:10.1177/002215549904700909. PMID 10449538.
- Kuwasako K; Kitamura K; Ito K et al. (2002). "The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors". J. Biol. Chem. 276 (52): 49459–49465. doi:10.1074/jbc.M108369200. PMID 11591721.
- Forneris M; Gottardo L; Albertin G et al. (2002). "Expression and function of adrenomedullin and its receptors in Conn's adenoma cells". Int. J. Mol. Med. 8 (6): 675–9. doi:10.3892/ijmm.8.6.675. PMID 11712085.
- Hänze J; Groneberg DA; Rose F et al. (2002). "Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia". Biochem. Biophys. Res. Commun. 291 (5): 1160–1165. doi:10.1006/bbrc.2002.6595. PMID 11883938.
- Dumont CE; Muff R; Flühmann B et al. (2003). "Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats". Brain Res. 955 (1–2): 64–71. doi:10.1016/S0006-8993(02)03365-6. PMID 12419522.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Chosa E; Hamada H; Kitamura K et al. (2003). "Expression of adrenomedullin and its receptor by chondrocyte phenotype cells". Biochem. Biophys. Res. Commun. 303 (1): 379–386. doi:10.1016/S0006-291X(03)00347-4. PMID 12646214.
- Xu P; Dai AG; Zhou HD et al. (2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]". Zhonghua Jie He He Hu Xi Za Zhi 26 (12): 765–8. PMID 14720432.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334.
External links
- "GPR182". IUPHAR GPCR Database. International Union of Pharmacology (IUPHAR). 2007-12-04. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3070.
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