Biology:MRGPRX2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[1][2] It is most abundant on cutaneous mast cells.
Agonists are gyrase inhibitors like ciprofloxacin and non-depolarizing neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.
See also
- MAS1 oncogene
References
- ↑ "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell 106 (5): 619–632. Sep 2001. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
- ↑ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117194.
Further reading
- Takeda S; Kadowaki S; Haga T et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–44404. 2004. doi:10.1074/jbc.M302456200. PMID 12915402.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334.
- Yang S; Liu Y; Lin AA et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID 15862286.
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