Biology:S1PR5
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.[1]
Agonists
Evolution
Paralogues for S1PR5 Gene [4]
See also
References
- ↑ "Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53637.
- ↑ "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry 58 (23): 9154–70. Nov 2015. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.
- ↑ "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat 23 (7): 817–41. Jul 2013. doi:10.1517/13543776.2013.783022. PMID 23541049.
- ↑ "GeneCards®: The Human Gene Database". https://www.genecards.org/cgi-bin/carddisp.pl?gene=S1PR5&keywords=s1pr5#paralogs.
Further reading
- "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8". The Journal of Biological Chemistry 275 (19): 14281–6. May 2000. doi:10.1074/jbc.275.19.14281. PMID 10799507.
- "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors". The Journal of Biological Chemistry 276 (8): 5692–9. Feb 2001. doi:10.1074/jbc.M003964200. PMID 11069896.
- "Sphingosine 1-phosphate receptors". Prostaglandins 64 (1–4): 135–142. Apr 2001. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
- "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors". Biochemistry 40 (46): 14053–60. Nov 2001. doi:10.1021/bi011606i. PMID 11705398.
- "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1–3): 97–101. Jun 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists". Biochemical Pharmacology 64 (8): 1243–50. Oct 2002. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605.
- "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1579 (2–3): 117–23. Dec 2002. doi:10.1016/S0167-4781(02)00529-8. PMID 12427546.
- "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". The Journal of Investigative Dermatology 120 (4): 693–700. Apr 2003. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
- "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers". Acta Histochemica 106 (5): 373–8. 2005. doi:10.1016/j.acthis.2004.08.002. PMID 15530552.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia 10: P281. Jun 2014. doi:10.1016/j.jalz.2014.07.153.
- "T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow". J Exp Med 206 (11): 2469–81. Oct 2009. doi:10.1084/jem.20090525. PMID 19808259.
External links
- "Lysophospholipid Receptors: S1P5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2997.
- Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/S1PR5.
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