Biology:FZD3
 Generic protein structure example |
Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[1][2][3]
Function
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[3]
The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[4][5]
See also
References
- ↑ "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun 271 (1): 8–14. Jun 2000. doi:10.1006/bbrc.2000.2578. PMID 10777673.
- ↑ "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun 273 (1): 27–34. Jul 2000. doi:10.1006/bbrc.2000.2882. PMID 10873558.
- ↑ 3.0 3.1 "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7976.
- ↑ "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife 2: e01482. Dec 2013. doi:10.7554/eLife.01482. PMID 24347548.
- ↑ "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A 111 (29): E3005-14. Jul 2014. doi:10.1073/pnas.1406399111. PMID 24799694. Bibcode: 2014PNAS..111E3005H.
Further reading
- Katoh M (2002). "GIPC gene family (Review).". Int. J. Mol. Med. 9 (6): 585–9. doi:10.3892/ijmm.9.6.585. PMID 12011974.
- "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. 1997. doi:10.1073/pnas.94.13.6770. PMID 9192640. Bibcode: 1997PNAS...94.6770F.
- "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.". Biochem. Biophys. Res. Commun. 263 (2): 384–8. 1999. doi:10.1006/bbrc.1999.1344. PMID 10491302.
- "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.". J. Invest. Dermatol. 116 (6): 940–6. 2001. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.
- "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.". Neurosci. Lett. 353 (1): 53–6. 2004. doi:10.1016/j.neulet.2003.09.017. PMID 14642436. http://ousar.lib.okayama-u.ac.jp/8380.
- "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. 2005. doi:10.1002/ajmg.b.30076. PMID 15274031.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. 2004. doi:10.1080/13816810490514270. PMID 15370539.
- "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.". Journal of Neural Transmission 112 (2): 303–7. 2005. doi:10.1007/s00702-004-0264-2. PMID 15657645.
External links
- "Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3061.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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