Biology:TAS2R4
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 Generic protein structure example |
Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.[1][2][3]
Function
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[3]
See also
References
- ↑ "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. Apr 2000. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
- ↑ "T2Rs function as bitter taste receptors". Cell 100 (6): 703–11. Apr 2000. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
- ↑ 3.0 3.1 "Entrez Gene: TAS2R4 taste receptor, type 2, member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50832.
Further reading
- Kinnamon SC (2000). "A plethora of taste receptors". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
- "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. 2002. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Firestein S (2000). "The good taste of genomics". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.
- "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601–4. 2000. doi:10.1038/35007072. PMID 10766242. Bibcode: 2000Natur.404..601M.
- "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. 2001. doi:10.1006/bbrc.2001.5136. PMID 11437385.
- "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell 112 (3): 293–301. 2003. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. 2005. doi:10.1093/molbev/msi027. PMID 15496549.
- "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics 170 (1): 313–26. 2006. doi:10.1534/genetics.104.037523. PMID 15744053.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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