Biology:FZD5
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Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[1][2][3]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.[3]
See also
References
- ↑ "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem 271 (8): 4468–76. Jun 1996. doi:10.1074/jbc.271.8.4468. PMID 8626800.
- ↑ "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol 19 (1): 105–10. Jun 2001. doi:10.3892/ijo.19.1.105. PMID 11408929.
- ↑ 3.0 3.1 "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7855.
Further reading
- "A member of the Frizzled protein family mediating axis induction by Wnt-5A.". Science 275 (5306): 1652–4. 1997. doi:10.1126/science.275.5306.1652. PMID 9054360. https://zenodo.org/record/1231094.
- "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. 1997. doi:10.1073/pnas.94.13.6770. PMID 9192640. Bibcode: 1997PNAS...94.6770F.
- "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. 1998. doi:10.1073/pnas.95.17.10164. PMID 9707618. Bibcode: 1998PNAS...9510164T.
- "LDL-receptor-related proteins in Wnt signal transduction.". Nature 407 (6803): 530–5. 2000. doi:10.1038/35035117. PMID 11029007. Bibcode: 2000Natur.407..530T.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.". Biochem. Biophys. Res. Commun. 286 (4): 771–8. 2001. doi:10.1006/bbrc.2001.5430. PMID 11520064.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.". J. Rheumatol. 31 (9): 1874–5. 2004. PMID 15338479.
- "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. 2004. doi:10.1080/13816810490514270. PMID 15370539.
- "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.". Biochem. Biophys. Res. Commun. 328 (2): 533–9. 2005. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.". Blood 108 (3): 965–73. 2006. doi:10.1182/blood-2005-12-5046. PMID 16601243.
- "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.". Dev. Cell 11 (2): 213–23. 2006. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.
- "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.". Int. J. Oncol. 30 (3): 751–5. 2007. doi:10.3892/ijo.30.3.751. PMID 17273778.
External links
- "Frizzled Receptors: FZD5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3063.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.