Biology:Endothelin A receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.

Interactions

Endothelin receptor type A has been shown to interact with HDAC7A and HTATIP.

See also

• Endothelin receptor

External links

• "Endothelin Receptors: ET_A". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2263. 

Further reading

• "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Japanese Circulation Journal 56 (Suppl 5): 1303–7. 1993. doi:10.1253/jcj.56.supplementv_1303. PMID 1291713. 
• "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor". The Journal of Biological Chemistry 267 (26): 18797–804. September 1992. doi:10.1016/S0021-9258(19)37031-0. PMID 1326535. 
• "Cloning and expression of a human endothelin receptor: subtype A". The American Journal of the Medical Sciences 304 (4): 231–8. October 1992. doi:10.1097/00000441-199210000-00002. PMID 1415318. 
• "Cloning and expression of human endothelin-1 receptor cDNA". FEBS Letters 287 (1–2): 23–6. August 1991. doi:10.1016/0014-5793(91)80007-P. PMID 1652463. 
• "Cloning and chromosomal localization of a human endothelin ETA receptor". Biochemical and Biophysical Research Communications 181 (1): 184–90. November 1991. doi:10.1016/S0006-291X(05)81399-3. PMID 1659806. 
• "Cloning and characterization of cDNA encoding human A-type endothelin receptor". Biochemical and Biophysical Research Communications 180 (3): 1265–72. November 1991. doi:10.1016/S0006-291X(05)81332-4. PMID 1719979. 
• "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor". Proceedings of the National Academy of Sciences of the United States of America 88 (8): 3185–9. April 1991. doi:10.1073/pnas.88.8.3185. PMID 1849646. Bibcode: 1991PNAS...88.3185L. 
• "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors". European Journal of Biochemistry 228 (1): 102–8. February 1995. doi:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989. 
• "Binding and functional properties of endothelin receptor subtypes in the human prostate". Molecular Pharmacology 45 (2): 306–11. February 1994. PMID 8114678. 
• "Molecular characterization of the 5'-flanking region of human genomic ETA gene". Biochemical and Biophysical Research Communications 190 (2): 332–9. January 1993. doi:10.1006/bbrc.1993.1052. PMID 8427579. 
• "Molecular characterization and regulation of the human endothelin receptors". The Journal of Biological Chemistry 268 (6): 3873–9. February 1993. doi:10.1016/S0021-9258(18)53554-7. PMID 8440682. 
• "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts". The Biochemical Journal 313 (3): 795–801. February 1996. doi:10.1042/bj3130795. PMID 8611157. 
• "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification". The Journal of Biological Chemistry 271 (34): 20811–9. August 1996. doi:10.1074/jbc.271.34.20811. PMID 8702836. 
• "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". The Journal of Biological Chemistry 272 (28): 17734–43. July 1997. doi:10.1074/jbc.272.28.17734. PMID 9211925. 
• "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3". The Journal of Clinical Endocrinology and Metabolism 82 (9): 3116–23. September 1997. doi:10.1210/jcem.82.9.4209. PMID 9284755. 
• "Variants of endothelin-1 and its receptors in atopic asthma". Biochemical and Biophysical Research Communications 262 (1): 259–62. August 1999. doi:10.1006/bbrc.1999.1158. PMID 10448102. 
• "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons". The Journal of Clinical Endocrinology and Metabolism 85 (4): 1658–65. April 2000. doi:10.1210/jcem.85.4.6565. PMID 10770212. 
• "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cellular and Molecular Neurobiology 20 (3): 305–17. June 2000. doi:10.1023/A:1007010125316. PMID 10789830. 
• "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry 276 (20): 16597–600. May 2001. doi:10.1074/jbc.C000909200. PMID 11262386. 
• "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways". The Journal of Biological Chemistry 276 (36): 34041–50. September 2001. doi:10.1074/jbc.M103243200. PMID 11382773. 
• "Endothelin". Pharmacological Reviews 68 (2): 357–418. April 2016. doi:10.1124/pr.115.011833. PMID 26956245. 
• "Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method". Scientific Reports 7 (1): 7577. August 2017. doi:10.1038/s41598-017-08096-6. PMID 28790412. Bibcode: 2017NatSR...7.7577H. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.