Biology:Frizzled-1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Frizzled-1 (Fz-1) is a protein that in humans is encoded by the FZD1 gene.[1][2]
Function
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.[2]
References
- ↑ "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications 252 (1): 117–22. Nov 1998. doi:10.1006/bbrc.1998.9607. PMID 9813155.
- ↑ 2.0 2.1 "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8321.
Further reading
- "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America 95 (17): 10164–9. Aug 1998. doi:10.1073/pnas.95.17.10164. PMID 9707618. Bibcode: 1998PNAS...9510164T.
- "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene 18 (44): 5959–66. Oct 1999. doi:10.1038/sj.onc.1202985. PMID 10557084.
- "The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn-Schmiedeberg's Archives of Pharmacology 365 (5): 341–8. May 2002. doi:10.1007/s00210-002-0540-3. PMID 12012019.
- "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Letters 521 (1–3): 185–9. Jun 2002. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
- "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". The Journal of Biological Chemistry 279 (17): 17535–42. Apr 2004. doi:10.1074/jbc.M311292200. PMID 14739301.
- "Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity". PLOS Biology 2 (7): E158. Jul 2004. doi:10.1371/journal.pbio.0020158. PMID 15252441.
- "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics 25 (2): 81–90. Jun 2004. doi:10.1080/13816810490514270. PMID 15370539.
- "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". Journal of Dermatological Science 42 (2): 111–9. May 2006. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268.
External links
- "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3059.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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