Biology:Parathyroid hormone 2 receptor
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Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.[1]
Function
The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.[1]
The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.[2]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: PTH2R parathyroid hormone 2 receptor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5746.
- ↑ "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.". Biochemical Pharmacology 127: 71–81. 2017. doi:10.1016/j.bcp.2016.12.013. PMID 28012961.
Further reading
- "Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.". J. Biol. Chem. 270 (26): 15455–8. 1995. doi:10.1074/jbc.270.26.15455. PMID 7797535.
- "Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.". Genomics 37 (1): 140–1. 1997. doi:10.1006/geno.1996.0532. PMID 8921382.
- "Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.". Mol. Endocrinol. 12 (2): 193–206. 1998. doi:10.1210/mend.12.2.0063. PMID 9482662.
- "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.". J. Biol. Chem. 275 (35): 27274–83. 2000. doi:10.1074/jbc.M003910200. PMID 10854439.
- "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.". Endocrinology 143 (3): 1047–57. 2002. doi:10.1210/endo.143.3.8698. PMID 11861531.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.". Clin. Nephrol. 59 (6): 429–35. 2003. doi:10.5414/CNP59429. PMID 12834174.
- "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.". Mol. Endocrinol. 18 (6): 1486–98. 2004. doi:10.1210/me.2003-0487. PMID 14988434.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803–7. 2005. doi:10.1016/j.febslet.2004.12.056. PMID 15670850.
- "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.". Biochemical Pharmacology 127: 71–81. 2017. doi:10.1016/j.bcp.2016.12.013. PMID 28012961.
External links
- "Parathyroid Hormone Receptors: PTH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2970.
- Receptor,+Parathyroid+Hormone,+Type+2 at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/Parathyroid hormone 2 receptor.
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