Biology:Pyroglutamylated RFamide peptide receptor
 Generic protein structure example |
Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.[1][2]
Function
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[1]
A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[3] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[4]
References
- ↑ 1.0 1.1 "Entrez Gene: GPR103 G protein-coupled receptor 103". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84109.
- ↑ "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. September 2001. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- ↑ "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. July 2003. doi:10.1074/jbc.M302945200. PMID 12714592.
- ↑ "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. November 2003. doi:10.1074/jbc.M305270200. PMID 12960173.
Further reading
- "Discovery and mapping of ten novel G protein-coupled receptor genes.". Gene 275 (1): 83–91. 2001. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.". J. Biol. Chem. 278 (30): 27652–7. 2003. doi:10.1074/jbc.M302945200. PMID 12714592.
- "A new peptidic ligand and its receptor regulating adrenal function in rats.". J. Biol. Chem. 278 (47): 46387–95. 2004. doi:10.1074/jbc.M305270200. PMID 12960173.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7438–43. 2006. doi:10.1073/pnas.0602371103. PMID 16648250. Bibcode: 2006PNAS..103.7438T.
External links
- "Peptide P518 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1347.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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