Biology:Neuromedin U receptor
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Short description: InterPro Family
| neuromedin U receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | NMUR1 |
| Alt. symbols | GPR66 |
| NCBI gene | 10316 |
| HGNC | 4518 |
| OMIM | 604153 |
| RefSeq | NM_006056 |
| UniProt | Q9HB89 |
| Other data | |
| Locus | Chr. 2 q37.1 |
| neuromedin U receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | NMUR2 |
| Alt. symbols | NMU2R |
| NCBI gene | 56923 |
| HGNC | 16454 |
| OMIM | 605108 |
| RefSeq | NM_020167 |
| UniProt | Q9GZQ4 |
| Other data | |
| Locus | Chr. 5 q33.1 |
The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S.[1] There are two subtypes of the neuromedin U receptor, each encoded by a separate gene (NMUR1, NMUR2).
Selective Ligands
Neuromedin U is an agonist at both the NMU1 and NMU2 subtypes, while neuromedin S is selective for NMU2, and is a more potent agonist at this subtype than neuromedin U.[2][3] Several other peptide and non-peptide ligands are also available for the NMU receptors.
Agonists
- Non-selective
- Neuromedin U
- non-peptide NMU modulators [4][5]
- NMU2 selective
Antagonists
- NMU2 selective
- R-PSOP [6]
References
- ↑ "Neuromedin U and its receptors: structure, function, and physiological roles". Pharmacological Reviews 56 (2): 231–48. June 2004. doi:10.1124/pr.56.2.3. PMID 15169928.
- ↑ "Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S". British Journal of Pharmacology 158 (1): 87–103. June 2009. doi:10.1111/j.1476-5381.2009.00252.x. PMID 19519756.
- ↑ "The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)". Endocrinology 150 (7): 3101–9. July 2009. doi:10.1210/en.2008-1772. PMID 19324999.
- ↑ "Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay". Acta Pharmacologica Sinica 29 (4): 517–27. April 2008. doi:10.1111/j.1745-7254.2008.00769.x. PMID 18358099.
- ↑ Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005
- ↑ "Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2". The Journal of Pharmacology and Experimental Therapeutics 330 (1): 268–75. July 2009. doi:10.1124/jpet.109.152967. PMID 19369576.
External links
- "Neuromedin U Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1312.
- Neuromedin+U+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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