Biology:GABBR2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABA_B2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.

Function

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]

Interactions

GABBR2 has been shown to interact with GABBR1.

See also

• GABAB receptor

Further reading

• "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature 396 (6712): 679–82. 1999. doi:10.1038/25354. PMID 9872316. Bibcode: 1998Natur.396..679W. 
• "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity". J. Biol. Chem. 274 (12): 7607–10. 1999. doi:10.1074/jbc.274.12.7607. PMID 10075644. 
• "Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9". Genomics 56 (3): 288–95. 1999. doi:10.1006/geno.1998.5706. PMID 10087195. 
• "Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1". Mol. Cell. Neurosci. 13 (3): 180–91. 1999. doi:10.1006/mcne.1999.0741. PMID 10328880. 
• "Distribution of the GABA(B) receptor subunit gb2 in rat CNS". Brain Res. 860 (1–2): 41–52. 2000. doi:10.1016/S0006-8993(00)01958-2. PMID 10727622. https://zenodo.org/record/1259551. 
• "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor". J. Pharmacol. Exp. Ther. 293 (2): 460–7. 2000. PMID 10773016. 
• "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. 2001. doi:10.1073/pnas.240452197. PMID 11087824. Bibcode: 2000PNAS...9713967W. 
• "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. 2002. doi:10.1523/JNEUROSCI.22-04-01280.2002. PMID 11850456. 
• "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. 2002. doi:10.1074/jbc.M201539200. PMID 11854302. 
• "Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy". Neurosci. Lett. 352 (2): 141–5. 2004. doi:10.1016/j.neulet.2003.08.046. PMID 14625043. 
• "Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits". J. Comp. Neurol. 470 (4): 339–56. 2004. doi:10.1002/cne.20005. PMID 14961561. 
• "Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking". J. Biol. Chem. 279 (18): 18840–50. 2004. doi:10.1074/jbc.M313470200. PMID 14966130. 
• "Characterization of GABAB receptor in the human colon". J. Pharmacol. Sci. 94 (2): 211–3. 2004. doi:10.1254/jphs.94.211. PMID 14978362. 
• "Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR". EMBO J. 24 (3): 499–509. 2005. doi:10.1038/sj.emboj.7600557. PMID 15660124. 
• "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. 2005. doi:10.1021/pr0498436. PMID 15822905. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Functional expression of the GABAB receptor in human airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923–31. 2006. doi:10.1152/ajplung.00185.2006. PMID 16829628. 

External links

• "GABA_B Receptors: GABA_B2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2933. 
• Overview of all the structural information available in the PDB for UniProt: O75899 (Gamma-aminobutyric acid type B receptor subunit 2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.