Biology:ADGRA3
From HandWiki
Adhesion G-protein coupled receptor A3 or (ADGRA3) is a protein that in humans is encoded by the ADGRA3 gene (previously GPR125)[1][2] It is an orphan receptor from the adhesion G protein-coupled receptor family.[3] It is missing a particular catalytic triad sequence in its GPS region, and so it is thought to not undergo autocatalytic cleavage in that region, unlike most members of its family.[3]
References
- ↑ "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. Feb 2003. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
- ↑ "Entrez Gene: GPR125 G protein-coupled receptor 125". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=166647.
- ↑ 3.0 3.1 "Q8IWK6 · AGRA3_HUMAN". UniProt consortium. https://www.uniprot.org/uniprotkb/Q8IWK6/entry.
Further reading
- Seandel M (2007). "Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.". Nature 449 (7160): 346–50. doi:10.1038/nature06129. PMID 17882221. Bibcode: 2007Natur.449..346S.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.". Oncogene 23 (22): 3889–97. 2004. doi:10.1038/sj.onc.1207495. PMID 15021905.
- "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. 2005. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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